Hydrochloric Acid → HCID 57810441, compound

Participants

Reaction Steps

Preparation according to Example 2: 4-(2,3-dichlorophenyl)piperidin-4-ol (0.44 g, 1.81 mmol), acetonitrile (20 ml), potassium carbonate (0.5 g, 3.6 mmol), 1-bromo-2-methoxyethane (0.17 ml, 2.0 mmol). Yield: 0.3 g, 54%. The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether. M.p. 135-137° C. MS m/z (relative intensity, 70 eV) 305 (M+, 1), 303 (M+, 1), 260 (63), 258 (bp) 240 (31).

Provenance & Evidence