Hydrochloric Acid → HCID 57810436, compound

Participants

Reaction Steps

Preparation according to Example 2: 4-[4-methyl-3-(trifluoromethyl)phenyl]piperidin-4-ol (0.5 g, 1.93 mmol), acetonitrile (20 ml), potassium carbonate (0.53 g, 3.8 mmol), 1-bromobutane (0.20 ml, 2.1 mmol). Yield: 0.48 g, 79%. The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 197-198° C. MS m/z (relative intensity, 70 eV) 315 (M+, 7), 272 (bp), 254 (48), 181 (38), 169 (25).

Provenance & Evidence