2,6-Difluorobenzoic acid → 2,6-difluoro-N-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-benzamide

HRID 2105969Notes

Reaction equation

HRID 2105969 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[N:14]=[C:15]([NH2:24])[S:16][C:17]=1[CH2:18][CH2:19][O:20][N+:21]([O-:23])=[O:22]>>[F:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:2]([F:1])[C:3]=1[C:4]([NH:24][C:15]1[S:16][C:17]([CH2:18][CH2:19][O:20][N+:21]([O-:23])=[O:22])=[C:13]([CH3:12])[N:14]=1)=[O:6]

Participants

3

Reactant 2

HCID 97962,6-Difluorobenzoic acidHCID 115574994-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine

Product 1

HCID 184408412,6-difluoro-N-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-benzamideYield 72%

Procedure

Pet-161 was prepared according to the general procedure described hereinabove and the procedure described above for the preparation of Pet-154, using 2,6-difluoro-benzoic acid and 4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine (Pet-10) as the starting materials, in an overall yield of 72%.

Workup

  1. customPet-161 was prepared
  2. customthe procedure described above for the preparation of Pet-154

Sources & evidence

ORD record
ord-598dc7e2f28c4d68ba7eab65619804f1
Source dataset
uspto-grants-2009_08
Patent number
US07579477B2

Reaction notes

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