Dichloromethane → HCID 69054751, compound

Participants

Reaction Steps

A mixture of 2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane (see Example 1) (0.139 g) and 3,4-dihydro-2H-benzo[1,4]oxazine (0.76 g) was dissolved in approximately 5 mL of methylene chloride and 0.55 g of flash silica gel was added. The volatiles were removed in vacuo and the residue was microwaved for 60 seconds at 150° C. and applied to a column of flash silica gel. Elution with EtOAc-hexanes (1:10) and concentration in vacuo of the product-rich fractions provided a residue which was dissolved in diethyl ether. HCl in dioxane was added. The volatiles were removed in vacuo and the residue triturated with diethyl ether. The resulting solid was dried in vacuo to provide the title compound, m.p. 98° C.-99° C.

Provenance & Evidence