Formaldehyde → HCID 178519804, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-hydroxyquinoline (5.0 g), aqueous sodium hydroxide solution (1M, 42 mL) and formaldehyde solution (37% in water, 6 mL) was heated at 45° C. for 18.5 hours. The reaction mixture was filtered, acidified with 2N HCl (21 mL) and extracted with ethyl acetate. The aqueous layer was chilled to afford 4-hydroxy-3-hydroxymethylquinoline (2.0 g) as a white solid.

Provenance & Evidence