Sodium Bicarbonate → HCID 57809756, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane (344 mg) and 4-hydroxy-3-hydroxymethylquinoline (412 mg) in anhydrous ethanol (2.5 mL) was added sodium ethoxide (21 wt. % solution in ethanol, 439 μL). After heating at 85° C. for 17 hours, the reaction mixture was poured into saturated aqueous sodium bicarbonate and extracted twice with ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by column chromatography with silica gel (eluted with 80%-100% ethyl acetate-hexanes) to give the title compound as a white solid (405 mg), m.p. 183° C.-184° C.

Provenance & Evidence