1-(2-Pyrimidinyl)piperazine → 4-Chloro-7-(1-(tert-butoxycarbonyl)-5-[4-(pyrimidin-2-yl)piperazin-1-ylmethyl]indol-2-yl)isoindolinone

Participants

Reaction Steps

In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 1-(2-pyrimidyl)piperazine (33 mg, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-(1-(tert-butoxycarbonyl)-5-[4-(pyrimidin-2-yl)piperazin-1-ylmethyl]indol-2-yl)isoindolinone.

Provenance & Evidence