Potassium Carbonate → HCID 57809771, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one (2.25 g, 5.14 mmol) in DMF (40 mL) was added potassium carbonate (2.13 g, 15.4 mmol) followed by heating to 120° C. in a sealed reaction vessel for 14 hours. The solution was diluted with 300 mL of diethyl ether, washed with one 200 mL portion of saturated aqueous sodium bicarbonate, three 100 mL portions of water, one 100 mL portion of brine, dried over anhydrous sodium sulfite (Na2SO3), and concentrated in vacuo. The crude material was purified by flash column chromatography (5% MeOH/CH2Cl2) to give 1-[4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentyl]-1H-quinolin-4-one as a brown foam (1.07 g, 57%).

Provenance & Evidence