反应详情

A mixture of N-bromosuccinimide (6.84 g, 38.42 mmol), benzoylperoxide (catalytic amount) and 1,1,1-trifluoro-4-(2-methoxyphenyl)-4-methylpentan-2-one (10.0 g, 38.42 mmol) in carbon tetrachloride (120 mL) and was refluxed for two days. After cooling, the solution was washed with water (60 mL) and 1.0M NaOH (60 mL), dried over sodium sulfate (Na2SO4), and concentrated in vacuo giving 1,1,1-trifluoro-4-(5-bromo-2-methoxyphenyl)-4-methylpentan-2-one and the starting material as 3:1 mixture (13.0 g).

1. temperaturewas refluxed for two days
2. temperatureAfter cooling
3. washthe solution was washed with water (60 mL) and 1.0M NaOH (60 mL)
4. dry with materialdried over sodium sulfate (Na2SO4)
5. concentrationconcentrated in vacuo