p-Toluenesulfonic acid → HCID 57810030, compound

Participants

Reaction Steps

A solution of 0.31 g of 7-[2-(2,2-dimethyl-4-trifluoromethyl-[1,3]dioxolan-4-yl)-1,1-dimethylethyl]-5-methylsulfanyl-2,3-dihydrobenzofuran and 0.015 g of p-toluenesulfonic acid (p-TsOH) monohydrate in methanol (10 mL) was stirred at room temperature for 7 days, heated to reflux for 1 minute, and the volatiles removed in vacuo. The residue was diluted with saturated aqueous sodium bicarbonate and filtered. The solid was washed with water and hexanes, and dried to give 0.235 g of 4-methyl-4-(5-methylsulfanyl-2,3-dihydrobenzofuran-7-yl)-2-trifluoromethylpentane-1,2-diol.

Provenance & Evidence