反应详情

To a solution of 3-methyl-3-(2-methoxy-5-fluorophenyl)butan-1-ol (3.30 g) in methylene chloride (40 mL) stirred at room temperature was added pyridinium chlorochromate (4.2 g) portionwise over 5 minutes. The mixture was stirred for 3 hours and then filtered through CELITE® filter aid. The solvent was evaporated in vacuo and the residue was fractionated by chromatography over silica gel (methylene chloride-hexane (1:3 to 1:1 gradient)) to give 3-methyl-3-(2-methoxy-5-fluorophenyl)butyraldehyde an oil (2.5 g, 76%).

1. filtrationfiltered through CELITE®
2. filtrationfilter aid
3. customThe solvent was evaporated in vacuo