Sodium Hydroxide → 1,1,-Difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one

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Reaction Steps

To a solution of [1,1-difluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentyl]phosphonic acid diethyl ester (1.0 g) in methanol (12.0 mL) was added a solution of sodium hydroxide (0.04 g) in water (1 mL). The mixture was stirred at room temperature for 30 minutes. The mixture was diluted with hexanes (50 mL) and water (50 mL) and the organic phase was separated, dried, filtered, and evaporated in vacuo to give 1,1,-difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one (0.63 g) as an oil which was used without additional purification.

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