HCID 274841, compound → HCID 59752550, compound

HRID 2106196Notes

Reaction equation

HRID 2106196 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[Br:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]=[CH:23][N+:24]([O-])=O)=[CH:18][CH:17]=1>C(N)C1C=CC=CC=1>[CH2:22]([N:24]1[C:11]2[CH2:10][CH2:9][NH:8][CH2:13][C:12]=2[C:22]([C:19]2[CH:20]=[CH:21][C:16]([Br:15])=[CH:17][CH:18]=2)=[CH:23]1)[C:19]1[CH:20]=[CH:21][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 274841HCID 274841, compoundHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 59752550HCID 59752550, compoundYield 74.9%

Reagents, catalysts & solvents 1

HCID 7504BenzylamineSolvent

Procedure

The title compound (0.38 g) was prepared from 0.66 g of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, 300 μL of benzylamine, and 0.63 g of 1-bromo-4-(2-nitro-vinyl)-benzene. MS (ESI): exact mass calculated for C20H19BrN2, 366.07; found, m/z 367.1 [M+H]+. 1H NMR (500 MHz, CD3OD): 7.51-7.48 (m, 2H), 7.36-7.32 (m, 2H), 7.30-7.25 (m, 3H), 7.19-7.16 (m, 2H), 5.14 (s, 2H), 4.35 (s, 2H), 3.50 (t, J=6.3 Hz, 2H), 2.87 (t, J=6.3 Hz, 2H).

Sources & evidence

ORD record
ord-6339fa59f3474c59bf79760cf9a5b5da
Source dataset
uspto-grants-2009_08
Patent number
US07579470B2

Reaction notes

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