3-(Methylamino)propane-1,2-diol → HCID 68492354, compound

Participants

Reaction Steps

In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 3-methylamino-1,2-propanediol (21 mg, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-{1-(tert-butoxycarbonyl)-5-[N-(2,3-dihydroxypropyl)-N-methylaminomethyl]indol-2-yl}isoindolinone.

Provenance & Evidence