HCID 86598383, compound → HCID 24871619, compound

HRID 2106305Notes

Reaction equation

HRID 2106305 reaction equation
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:11](=[C:12](OS(C(F)(F)F)(=O)=O)[N:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=3)[N:14]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>O1CCOCC1>[F:24][C:20]1[CH:19]=[C:18]([N:13]2[C:12]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[C:11]3[C:15]([CH2:16][CH2:17][NH:8][CH2:9][CH2:10]3)=[N:14]2)[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 1

HCID 86598383HCID 86598383, compound

Product 1

HCID 24871619HCID 24871619, compoundYield 34.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound (37.6 mg) was prepared from 339.2 mg of 2-(3-fluoro-phenyl)-3-trifluoromethanesulfonyloxy-4,5,7,8-tetrahydro-2H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester (made as in Example 176, Steps A and B from (3-fluoro-phenyl)-hydrazine) as described in Example 196, using 1,4-dioxane as the solvent. MS (ESI): exact mass calculated for C19H18FN3,307.15 307.15; found, m/z 308.1 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.39-7.35 (m, 3H), 7.20-7.14 (m, 3H), 7.00-6.96 (m, 1H), 6.94-6.86 (m, 2H), 3.13-3.09 (m, 2H), 3.06-3.02 (m, 2H), 3.01-2.96 (m, 2H), 2.69-2.66 (m, 2H).

Sources & evidence

ORD record
ord-a9bc648b0c7446439ed5ef5282d85a06
Source dataset
uspto-grants-2009_08
Patent number
US07579470B2

Reaction notes

Loading…