O-Cresol → HCID 57810551, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(1-ethyl-1-hydroxy-propyl)-benzofuran-5-carboxylic acid methyl ester (6.01 g, 22.9 mmol) and o-cresol (3.71 g, 34.4 mmol) in CH2Cl2 (150 mL) at −78° C. is added BF3-Et2O (1.63 ml, 11.5 mol). After stirring for 5 min, the reaction mixture is allowed to warm up to 0° C. over 30 min. The reaction is quenched with water (50 mL) and extracted with CH2Cl2 (50 mL). The organic layer is dried over Na2SO4, concentrated, purified on column chromatography (15-20% EtOAc/Hex) to afford the title compound (7.38 g, 91%).

Provenance & Evidence