Potassium Carbonate → HCID 68813225, compound

Participants

Reaction Steps

A solution of 2-[1-ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-benzofuran-5-carboxylic acid methyl ester (4.25 g, 12.1 mmol) and 1-bromopinacolone (2.70 g, 15.1 mmol) in acetone (80 mL) is treated with K2CO3 (3.33 g, 24.1 mmol) and stirred at RT for 18 h. The solid is filtered and the filtrate is concentrated, the residue is purified on column chromatography with 10-15% EtOAc/Hexane to provide the title compound (4.90 g, 90%).

Provenance & Evidence