Sodium Hydroxide → HCID 68817136, compound

Participants

Reaction Steps

A solution of 2-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-ethylpropyl}-benzofuran-5-carboxylic acid methyl ester (5.30 g, 11.8 μmmol) in methanol (30.0 mL) and THF (30.0 mL) is treated with NaOH (2.0 M, 60 mL). The resulting mixture is stirred at RT for 16 h. The mixture is concentrated and neutralized with HCl (5 N) till pH˜3, and extracted with EtOAc (2×100 mL). The organic layer is dried over Na2SO4, concentrated to afford the title compound (4.85 g, 94%).

Provenance & Evidence