Sodium Hydroxide → HCID 11259190, compound

Participants

Reaction Steps

A solution of 2-{1-ethyl-1-[4-(2-hydroxy-3,3-dimethyl-butoxy)-3-methyl-phenyl]-propyl}-benzofuran-5-carboxylic acid methyl ester (555 mg, 1.226 mmol) in methanol (3.0 mL) and THF (3.0 mL) and is treated with NaOH (2.0 M, 6.0 mL). The resulting mixture is stirred at RT for 18 h. The mixture is concentrated and neutralized with HCl (1 N) till pH˜2, and extracted with EtOAc (3×10 mL). The organic layer is dried over Na2SO4, concentrated to afford the title compound (530 mg, 99%).

Provenance & Evidence