Sodium Hydroxide → HCID 68815364, compound

Participants

Reaction Steps

A solution of 2-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-ethyl-phenyl]-ethylpropyl}-benzofuran-5-carboxylic acid methyl ester (1.64 g, 3.53 mmol) in methanol (5.0 mL) and THF (5.0 mL) is treated with NaOH (2.0 M, 10 mL). The resulting mixture is stirred at RT for 12 h. The mixture is concentrated and neutralized with HCl (5 N) until pH˜3, and extracted with EtOAc (3×30 mL). The organic layer is dried over Na2SO4, concentrated to afford the title compound (1.57 g, 99%).

Provenance & Evidence