Sodium borohydride → HCID 11224771, compound

Participants

Reaction Steps

A solution of 5-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-7-methyl-benzofuran-2-carboxylic acid (250 mg, 0.555 mmol) in THF (10 mL) at RT is treated with NaBH4 (42 mg, 1.11 mmol). The resulting mixture is stirred for 60 min and is quenched with HCl (1.0 N, 5.0 mL) and extracted with EtOAc (2×30 mL). The organic layer is dried over Na2SO4, concentrated to afford the title compound (170 mg, 68%).

Provenance & Evidence