Boron trifluoride etherate → HCID 11352408, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-7-methyl-benzofuran-2-carboxylic acid ethyl ester (506 mg, 1.06 mmol) in ethylene glycol (5.0 mL) is treated with BF3-Et2O (3.0 ml). The reaction mixture is heated to 80° C. and stirred for 3 h. The reaction is quenched with water (20 mL) and extracted with CH2Cl2 (30×2 mL). The organic layer is dried over Na2SO4, concentrated, purified on column chromatography (8% EtOAc/Hex) to afford the title compound (550 mg, 99%).

Provenance & Evidence