1,2-Dichloroethane → HCID 11364880, compound

Participants

Reaction Steps

5-{1-[4-(2-tert-Butyl-[1,3]dioxolan-2-ylmethoxy)-3-methyl-phenyl]-1-ethylpropyl}-7-methyl-benzofuran-2-carboxylic acid (180 mg, 0.364 mmol), EDC (105 mg, 0.546 mmol), DMAP (133 mg, 1.09 mmol, and glycine methyl ester hydrochloride (68 mg, 0.55 mmol) are reacted to produce the intermediate followed by hydrolysis analogous to Example 7 to give title compound (195 mg, 97%).

Provenance & Evidence