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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2106457Generated: November 1, 2026

1,2-Dichloroethane → HCID 11466045, compound

https://huagongshe.com/reaction/2106457

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-DichloroethaneHCID 11—
ReactantGlycine methyl ester hydrochlorideHCID 122755—
ReactantHCID 11396452HCID 11396452—
Catalyst4-(Dimethylamino)pyridineHCID 14284—
SolventDichloromethaneHCID 6344—
ProductHCID 11466045HCID 1146604548.6%

Reaction Steps

5-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzofuran-2-carboxylic acid (730 mg, 1.672 mmol) in CH2Cl2 (30 mL) and DMAP (612 mg, 5.02 mmol), EDC (481 mg, 2.51 mmol), and glycine methyl ester hydrochloride (313 mg, 2.51 mmol) are reacted and hydrolyzed analogous to Example 7 to yield title compound (401 mg, 47%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07579488B2
Source datasetuspto-grants-2009_08
ORD IDord-681ad36551454d1cb7c2e3ae177dda64
Source noteuspto-grants-2009_08