Water → HCID 57810541, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-[2-acetyl-4-(1-ethyl-propenyl)-phenoxy]-3,3-dimethyl-butan-2-one (4.80 g, 16.5 mmol) in DMF (40 mL) is treated with DBU (2.51 g, 16.5 mmol) and the solution is heated to 140° C. for 2 h. The reaction mixture is cooled down and poured into water (400 mL) and extracted with EtOAc (2×100 mL). The organic layer is dried over Na2SO4, concentrated, purified on column chromatography (5% EtOAc/Hex) to give the title compound as an oil (3.20 g, 71%)

Provenance & Evidence