HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 11420801, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | HCID 11328417 | HCID 11328417 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11420801 | HCID 11420801 | 100% |
Reaction Steps
5-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-3-methyl-benzofuran-2-carboxylic acid (520 mg, 1.154 mmol) in CH2Cl2 (10 mL) and DMAP (422 mg, 3.46 mmol), EDC (332 mg, 1.73 mmol), and glycine methyl ester hydrochloride (217 mg, 1.73 mmol) are reacted and hydrolyzed analogous to Example 7 to yield title compound (390 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07579488B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-57ca970c60f94df7ba0308b5ace1000c |
| Source note | uspto-grants-2009_08 |