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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2106465Generated: October 30, 2026

1,2-Dichloroethane → HCID 11420801, compound

https://huagongshe.com/reaction/2106465

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-DichloroethaneHCID 11—
ReactantGlycine methyl ester hydrochlorideHCID 122755—
ReactantHCID 11328417HCID 11328417—
Catalyst4-(Dimethylamino)pyridineHCID 14284—
SolventDichloromethaneHCID 6344—
ProductHCID 11420801HCID 11420801100%

Reaction Steps

5-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-3-methyl-benzofuran-2-carboxylic acid (520 mg, 1.154 mmol) in CH2Cl2 (10 mL) and DMAP (422 mg, 3.46 mmol), EDC (332 mg, 1.73 mmol), and glycine methyl ester hydrochloride (217 mg, 1.73 mmol) are reacted and hydrolyzed analogous to Example 7 to yield title compound (390 mg, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07579488B2
Source datasetuspto-grants-2009_08
ORD IDord-57ca970c60f94df7ba0308b5ace1000c
Source noteuspto-grants-2009_08