HCID 57810560, compound → HCID 57810550, compound

HRID 2106478Notes

Reaction equation

HRID 2106478 reaction equation
C([O:8][C:9]1[CH:10]=[CH:11][C:12]2[O:16][C:15]([C:17]([C:22]3[CH:35]=[CH:34][C:25]([O:26][CH2:27][C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])=[C:24]([CH3:36])[CH:23]=3)([CH2:20][CH3:21])[CH2:18][CH3:19])=[CH:14][C:13]=2[CH:37]=1)C1C=CC=CC=1>[Pd]>[CH2:18]([C:17]([C:22]1[CH:35]=[CH:34][C:25]([O:26][CH2:27][C:28](=[O:33])[C:29]([CH3:30])([CH3:32])[CH3:31])=[C:24]([CH3:36])[CH:23]=1)([C:15]1[O:16][C:12]2[CH:11]=[CH:10][C:9]([OH:8])=[CH:37][C:13]=2[CH:14]=1)[CH2:20][CH3:21])[CH3:19]

Participants

3

Reactant 1

HCID 57810560HCID 57810560, compound

Product 1

HCID 57810550HCID 57810550, compoundYield 95.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1-{4-[1-(5-Benzyloxy-benzofuran-2-yl)-1-ethyl-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one (3.20 g, 6.42 mmol) and Pd—C (0.20 g) are reacted under hydrogen analogous to Example 18-F to give the title compound (2.50 g, 95%).

Sources & evidence

ORD record
ord-53776a9e65894cdd9d7cf496689868d1
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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