Aluminium lithium hydride → HCID 57810569, compound

Participants

Reaction Steps

A solution of 2-[1-ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-benzofuran-5-carboxylic acid methyl ester (710 mg, 2.02 mmol) in THF (40 mL) at 0° C. are added with LAH (153 mg, 4.03 mmol) and the mixture are stirred for 30 minutes. The reaction is quenched with water (0.5 mL), then NaOH (5N, 3.0 mL) and stirred for 10 minutes. The organic layer is concentrated and loaded on column and purified with EtOAc/Hexanes (50%) to obtain the title compound (653 mg, 100%).

Provenance & Evidence