Sodium borohydride → HCID 68813830, compound

Participants

Reaction Steps

A solution of [(2-{1-[4-(4,4-Dimethyl-3-oxo-pentyl)-3-isopropyl-phenyl]-1-ethyl-propyl}-benzofuran-5-carbonyl)-methyl-amino]-acetic acid (27 mg, 0.05 mmol) (Example 55) in THF (2 mL) is treated with NaBH4 (4 mg, 0.1 mmol) at room temp. The resulting mixture is stirred for 2 hours. The mixture is concentrated and neutralized to pH 3 and extracted with EtOAc (3×5 mL). The organic layer is dried over sodium sulfate, concentrated to afford the desired compound. (17 mg, 63%) MS (ES) m/e: 536.3 (M−1)

Provenance & Evidence