Tetrahydrofuran → HCID 57810547, compound

Participants

Reaction Steps

A solution of (6-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzofuran-2-carbonyl)-amino]-acetic acid (66 mg, 0.130 mmol) (Example 57) in THF (2 mL) is treated with NaBH4 (11 mg, 0.26 mmol) at room temp. The resulting mixture is stirred for 2 hours. The mixture is concentrated and neutralized to pH 3 and extracted with EtOAc (3×5 mL). The organic layer is dried over sodium sulfate, concentrated to afford the desired compound (39 mg, 59%). MS (ES) m/e: 508.3 (M−1)

Provenance & Evidence