Sodium borohydride → HCID 11178082, compound

HRID 2106494Notes

Reaction equation

HRID 2106494 reaction equation
[CH2:1]([C:3]([C:21]1[CH:22]=[CH:23][C:24]2[O:28][C:27]([C:29]([OH:31])=[O:30])=[CH:26][C:25]=2[CH:32]=1)([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]2=[O:19])=[C:8]([CH3:20])[CH:7]=1)[CH2:4][CH3:5])[CH3:2].[BH4-].[Na+]>>[CH2:1]([C:3]([C:21]1[CH:22]=[CH:23][C:24]2[O:28][C:27]([C:29]([OH:31])=[O:30])=[CH:26][C:25]=2[CH:32]=1)([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]2[OH:19])=[C:8]([CH3:20])[CH:7]=1)[CH2:4][CH3:5])[CH3:2]

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 11178032HCID 11178032, compound

Product 1

HCID 11178082HCID 11178082, compoundYield 65%

Procedure

5-{1-Ethyl-1-[3-methyl-4-(2-oxo-cyclohexyloxy)-phenyl]-propyl}-benzofuran-2-carboxylic acid (357 mg, 0.822 mmol) (Example N) was reacted with sodium borohydride (68 mg, 1.6 mmol) in an analogous manner to Example 31 to yield (13 mg, 65% yield).

Workup

  1. customto yield (13 mg, 65% yield)

Sources & evidence

ORD record
ord-cb3fc7a539c742e9814b9c0fe3bab6d2
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

Loading…