Sodium borohydride → HCID 11178771, compound

HRID 2106495Notes

Reaction equation

[CH3:1][C:2]1([CH3:34])[CH2:7][CH2:6][CH2:5][CH:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:20]3[CH:21]=[CH:22][C:23]4[O:27][C:26]([C:28]([OH:30])=[O:29])=[CH:25][C:24]=4[CH:31]=3)([CH2:18][CH3:19])[CH2:16][CH3:17])=[CH:11][C:10]=2[CH3:32])[C:3]1=[O:33].[BH4-].[Na+]>>[CH2:16]([C:15]([C:20]1[CH:21]=[CH:22][C:23]2[O:27][C:26]([C:28]([OH:30])=[O:29])=[CH:25][C:24]=2[CH:31]=1)([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH:4]2[CH2:5][CH2:6][CH2:7][C:2]([CH3:1])([CH3:34])[CH:3]2[OH:33])=[C:10]([CH3:32])[CH:11]=1)[CH2:18][CH3:19])[CH3:17]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 11167139HCID 11167139, compound

Product 1

HCID 11178771HCID 11178771, compoundYield 64%

Procedure

5-{1-[4-(3,3-Dimethyl-2-oxo-cyclohexyloxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzofuran-2-carboxylic acid (200 mg, 0.432 mmol) (Example 67) is reacted with sodium borohydride (36 mg, 0.864 mmol) in an analogous manner to Example 31 to yield (13 mg, 64% yield). MS (ES) m/e: 563.3 (M−1)

Workup

customto yield (13 mg, 64% yield)

Sources & evidence

ORD record: ord-137fb045813d43d6aaa09ddee0dff201
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579488B2

Reaction notes

Loading…