1,2-Dichloroethane → HCID 57810584, compound

Participants

Reaction Steps

A solution of 5-{1-[4-(3,3-Dimethyl-2-oxo-cyclohexyloxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzofuran-2-carboxylic acid (100 mg, 0.204 mmol) (from example 73A), EDC (58 mg, 0.306 mmol), HOBT (32 mg, 0.244 mmol), triethylamine (0.1 ml, 0.816 mmol), and L-valine methyl ester hydrochloride (41 mg, 0.244 mmol) were reacted followed by base hydrolysis as in Example 74 to yield (80 mg, 68%) MS (ES) m/e: 574.3 (M−1)

Provenance & Evidence