Ethyl [4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetate → Ethyl [4-(4-methyl-piperidin-4-yl)-piperazin-1-yl]acetate

HRID 2106509Notes

Reaction equation

HRID 2106509 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2([CH3:25])[CH2:17][CH2:16][N:15](CC3C=CC=CC=3)[CH2:14][CH2:13]2)[CH2:8][CH2:7]1)[CH3:2].[H][H]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2([CH3:25])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH2:8][CH2:7]1)[CH3:2]

Participants

5

Reactant 2

HCID 86650916Ethyl [4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetateHCID 178418361HCID 178418361, compound

Product 1

HCID 57807651Ethyl [4-(4-methyl-piperidin-4-yl)-piperazin-1-yl]acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 0.44 g (1.10 mmol) ethyl[4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetate and 100 mg 10% Pd/C in 20 mL EtOH was hydrogenated for 12 h at 50° C. and 3447 hPa hydrogen pressure. The catalyst was filtered off and the filtrate was evaporated to dryness. The product was reacted further without purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated to dryness
  3. customThe product was reacted further without purification

Sources & evidence

ORD record
ord-4cf5e50a989243b2b93e55ea59914bd0
Source dataset
uspto-grants-2009_08
Patent number
US07579341B2

Reaction notes

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