Ethanol → HCID 57807684, compound

HRID 2106511Notes

Reaction equation

HRID 2106511 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([N:8]2[CH2:13][CH2:12][N:11](C(OCCCC3C=CC=CC=3)=O)[C@H:10]([C:26]([O-:28])=[O:27])[CH2:9]2)[CH2:4][CH2:3]1.[H][H].[CH3:31][CH2:32]O>[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([N:8]2[CH2:13][CH2:12][NH:11][C@H:10]([C:26]([O:28][CH2:31][CH3:32])=[O:27])[CH2:9]2)[CH2:6][CH2:7]1

Participants

5

Reactant 3

HCID 702EthanolHCID 86650919HCID 86650919, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57807684HCID 57807684, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A suspension of 2.15 g (5.52 mmol) 1-benzyl-2-ethyl(S)-4-(1-methyl-piperidin-4-yl)-piperazine-1,2-dicarboxylate and 100 mg 10% Pd/C in 50 mL EtOH was hydrogenated for 2 h at 50° C. and 3447 hPa hydrogen pressure. The catalyst was filtered off and the filtrate was evaporated to dryness. The product was reacted further without purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated to dryness
  3. customThe product was reacted further without purification

Sources & evidence

ORD record
ord-e341c64fcf884f48afd8a0c2e962dec2
Source dataset
uspto-grants-2009_08
Patent number
US07579341B2

Reaction notes

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