Triethylamine → HCID 66942052, compound

Participants

Reaction Steps

90 mg (0.28 mmol) TBTU, 39 μL (0.15 mmol) triethylamine and 29 mg (0.28 mmol) 2-hydroxy-N,N-dimethyl-acetamide were added to a solution of 190 mg (0.25 mmol) (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-[4-(4-carboxymethyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate in 5 mL DMF and the reaction mixture was stirred overnight at RT. The reaction solution was filtered through a syringe filter and the crude product was purified by HPLC. The fractions containing the product were combined and freeze-dried.

Provenance & Evidence