HCID 57807712, compound → HCID 57807461, compound

HRID 2106553Notes

Reaction equation

HRID 2106553 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:32]([OH:34])=O)[CH2:19][C:20]3[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[C:23]([NH2:30])=[C:22]([Cl:31])[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:35]=[CH:36][CH:37]=[CH:38][C:4]=2[NH:3]1.[N:39]1([CH:52]2[CH2:57][CH2:56][NH:55][CH2:54][CH2:53]2)[CH2:44][CH2:43][CH:42]([CH2:45][CH2:46][C:47]([O:49][CH2:50][CH3:51])=[O:48])[CH2:41][CH2:40]1>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C@H:18]([CH2:19][C:20]3[CH:25]=[C:24]([C:26]([F:28])([F:29])[F:27])[C:23]([NH2:30])=[C:22]([Cl:31])[CH:21]=3)[C:32]([N:55]3[CH2:54][CH2:53][CH:52]([N:39]4[CH2:44][CH2:43][CH:42]([CH2:45][CH2:46][C:47]([O:49][CH2:50][CH3:51])=[O:48])[CH2:41][CH2:40]4)[CH2:57][CH2:56]3)=[O:34])=[O:16])[CH2:13][CH2:14]2)[CH2:7][CH2:6][C:5]2[CH:35]=[CH:36][CH:37]=[CH:38][C:4]=2[NH:3]1

Participants

3

Reactant 2

HCID 57807712HCID 57807712, compoundHCID 58202073(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-carboxy-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate

Product 1

HCID 57807461HCID 57807461, compound

Procedure

Prepared analogously to Example 24 from 500 mg (0.90 mmol) (R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-carboxy-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate (Example 1f) and 341 mg (1.00 mmol) ethyl 3-[1,4′]bipiperidinyl-4-yl-propionate (Example A15b).

Sources & evidence

ORD record
ord-050905c00e7341fbbfa2fd8d77bd748e
Source dataset
uspto-grants-2009_08
Patent number
US07579341B2

Reaction notes

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