Lithium Hydroxide → HCID 57807502, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2.00 mg (0.08 mmol) LiOH in 1 mL water was added to 40 mg (0.05 mmol) ethyl 1′-{(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyloxy]-propionyl}-4-methyl-1,4′-bipiperidinyl-4-carboxylate in 0.8 mL THF and the reaction mixture was stirred for 1 h at RT and for 8 h at 50° C. This was purified by HPLC without working up; the fractions containing the product were combined and lyophilised.

Provenance & Evidence