Ammonium Carbonate → 1-methyl-1H-pyrazole-3-sulfonamide

HRID 2106563Notes

Reaction equation

HRID 2106563 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[N:3]1.C(=O)([O-])[O-].[NH4+:15].[NH4+]>C(Cl)(Cl)Cl>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([S:7]([NH2:15])(=[O:9])=[O:8])=[N:3]1

Participants

4

Reactant 2

HCID 517111Ammonium CarbonateHCID 134744661-Methyl-1H-pyrazole-3-sulfonyl chloride

Product 1

HCID 148356431-methyl-1H-pyrazole-3-sulfonamide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture containing chloroform (100 ml), 13.6 g of 1-methylpyrazole-3-sulfonyl chloride and 13.6 g ammonium carbonate was heated to reflux for six hours, cooled, filtered and the solid was washed with water. The water-insoluble solid which was recrystallized from 50% ethanol-water melted at 149°-151° and showed absorption peaks in the infrared at 3100 and 3200 cm-1, consistent for the NH2 in the desired product.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for six hours
  3. temperaturecooled
  4. filtrationfiltered
  5. washthe solid was washed with water
  6. customThe water-insoluble solid which was recrystallized from 50% ethanol-water melted at 149°-151°
  7. customabsorption peaks in the

Sources & evidence

ORD record
ord-f8bfc55808214937a8bc86443900b359
Source dataset
uspto-grants-1990_06
Patent number
US04931081

Reaction notes

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