(2,4-Dichlorophenyl)hydrazine monohydrochloride → 2-(2,4-Dichlorophenyl)hydrazine-1-carboxamide

HRID 2106565Notes

Reaction equation

HRID 2106565 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[NH:10][NH2:11].[O-:12][C:13]#[N:14].[K+]>O>[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[NH:10][NH:11][C:13]([NH2:14])=[O:12]

Participants

4

Reactant 2

HCID 2723905(2,4-Dichlorophenyl)hydrazine monohydrochlorideHCID 11378442Potassium cyanate

Product 1

HCID 142687812-(2,4-Dichlorophenyl)hydrazine-1-carboxamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A 20 g portion of 2,4-dichlorophenylhydrazine hydrochloride was added to 200 ml of water and the solution was heated to 80°. Then 6.8 g of potassium cyanate was dissolved in 75 ml of water, and that solution was added dropwise to the first solution. The mixture was stirred for 4 hours at 80°, and it was then cooled. The product was collected by filtration, dried, and recrystallized from ethanol to obtain 11.8 g of the desired intermediate.

Workup

  1. temperaturethe solution was heated to 80°
  2. additionthat solution was added dropwise to the first solution
  3. temperatureit was then cooled
  4. filtrationThe product was collected by filtration
  5. customdried
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-9eef330cb6324dfda4a2e23de8a0afa9
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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