HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Ethyl 2-{[1-(3-chlorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl]oxy}propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ethyl 2-bromopropionate | HCID 79040 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 178433515 | HCID 178433515 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ethyl 2-{[1-(3-chlorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl]oxy}propanoate | HCID 163821 | 68% |
Reaction Steps
The process was carried out as was Example 9 above, starting with 0.8 g of sodium, 20 ml of methanol, 75 ml of dimethylsulfoxide, 7.8 g of 1-(3-chlorophenyl)-3-hydroxy-5-methyl-1,2,4-1H-triazole and 6.7 g of ethyl 2-bromopropionate. The yield was 7.8 g of the desired product, an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931083 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-7bdb0280f5674c1ca46931c397fad17e |
| Source note | uspto-grants-1990_06 |