Cyclopropylamine → HCID 15016303, compound

HRID 2106621Notes

Reaction equation

HRID 2106621 reaction equation
[C:1]([CH:4]([O:6][C:7]1[N:11]=[CH:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)[N:8]=1)[CH3:5])([OH:3])=O.[CH:22]1([NH2:25])[CH2:24][CH2:23]1>>[CH:22]1([NH:25][C:1]([CH:4]([O:6][C:7]2[N:11]=[CH:10][N:9]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=3)[N:8]=2)[CH3:5])=[O:3])[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 15016300HCID 15016300, compound

Product 1

HCID 15016303HCID 15016303, compound

Procedure

Three g of the product of Example 65 was reacted with 1.1 g of cyclopropylamine, substantially as shown in Example 60, to obtain 2.6 g of the desired product, m.p. 175°-177°.

Sources & evidence

ORD record
ord-88e85fd4be95411f9b45f4f9079e4118
Source dataset
uspto-grants-1990_06
Patent number
US04931083

Reaction notes

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