HRID2106626

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

HCID66980

Dodecanoic acid, 2-bromo-

C12H23BrO2

HCID1268121

Trithiocyanuric acid

C3H3N3S3

PRODUCTS

生成物

结构：CCCCCCCCCCC(Sc1nc(SC(CCCCCCCCCC)C(=O)O)nc(SC(CCCCCCCCCC)C(=O)O)n1)C(=O)O

HCID67893990

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A stirred solution of KOH (12.8 g; 0.228 mole) in ethanol (350 ml) is cooled to 10° C. and treated with trithiocyanuric acid (6.8 g; 0.038 mole). After stirring for 30 minutes, the reaction mixture is treated with 2-bromododecanoic acid (31.8 g; 0.114 mole) in small portions over 10-15 minutes. The resulting thick, white suspension is stirred for a further 30 minutes at 10° C. and is then allowed to warm to ambient temperature. Upon reaching ambient temperature the reaction mixture is heated to reflux and maintained at this temperature for 6 hours.

WORKUP

后处理

stirringThe resulting thick, white suspension is stirred for a further 30 minutes at 10° C.
customUpon reaching ambient temperature
temperatureis heated
temperatureto reflux
temperaturemaintained at this temperature for 6 hours

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f154728abb6441f8b4a22b5e2c6d8f46
来源数据集: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04931196
来源说明: uspto-grants-1990_06

反应 SMILES

[OH-:1].[K+].[NH:3]1[C:10](=[S:11])[NH:9][C:7](=[S:8])[NH:6][C:4]1=[S:5].Br[CH:13]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:14]([OH:16])=[O:15]>C(O)C>[N:3]1[C:10]([S:11][CH:13]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:14]([OH:16])=[O:15])=[N:9][C:7]([S:8][CH:13]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:14]([OH:15])=[O:1])=[N:6][C:4]=1[S:5][CH:13]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:14]([OH:16])=[O:15]