HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → N-Despropyl-rotigotine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 5-Methoxy-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride | HCID 13564363 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Despropyl-rotigotine | HCID 15107528 | 24.4% |
Reaction Steps
To a solution of 4.95 g (0.015 mol) of the product of Step 3 in dry dichloromethane was added 80 mL of boron tribromide under N2. The mixture was stirred 1 hour at room temperature then poured over NH4OH and ice. The organic layer was separated and dried over MgSO4, and concentrated to yield 1.0 g of product: NMR (CDCl3)δ7.2-6.6(6H,m), 3.1-2.8(7H,m), 2.7-2.5(2H,m), 2.15(1H,m), 1.65(1H,m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04931270 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-966f6e4454fb474695a54b6a34ce5442 |
| Source note | uspto-grants-1990_06 |