HRID2106653

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7504

Benzylamine

C7H9N

结构：O=C(O)CCC(=O)c1ccc(CCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1

HCID14423684

未命名化合物

PRODUCTS

生成物

结构：O=C1CCC(c2ccc(CCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)cc2)N1Cc1ccccc1

HCID23048804

未命名化合物

PROCEDURE

实验过程

4-Oxo-4-[4-(4-(4-(3-trifluoromethylphenyl)piperazin-1-yl)butyl)phenyl]butyric acid and benzylamine are reacted together to give N-benzyl-5-[4-(4-(4-(3-trifluoromethylphenyl)piperazin-1-yl)butyl)phenyl ]pyrrolidin-2-one.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-98d6e91f81aa488299c6d1c436c16875
来源数据集: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04931443
来源说明: uspto-grants-1990_06

反应 SMILES

O=[C:2]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=3)[CH2:20][CH2:19]2)=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5](O)=[O:6].[CH2:34]([NH2:41])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[CH2:34]([N:41]1[CH:2]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][N:21]([C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:31])([F:33])[F:32])[CH:25]=4)[CH2:20][CH2:19]3)=[CH:10][CH:9]=2)[CH2:3][CH2:4][C:5]1=[O:6])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1