1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 23048822, compound

HRID 2106656Notes

Reaction equation

HRID 2106656 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][N:10]2[CH:14]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][CH2:24]OS(C4C=CC(C)=CC=4)(=O)=O)=[CH:17][CH:16]=3)[CH2:13][CH2:12][C:11]2=[O:36])[CH2:3][CH2:2]1.[F:37][C:38]([F:52])([F:51])[C:39]1[CH:40]=[C:41]([N:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)[CH:42]=[CH:43][CH:44]=1>>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][CH2:9][N:10]2[CH:14]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][CH2:24][N:48]4[CH2:47][CH2:46][N:45]([C:41]5[CH:42]=[CH:43][CH:44]=[C:39]([C:38]([F:51])([F:52])[F:37])[CH:40]=5)[CH2:50][CH2:49]4)=[CH:17][CH:16]=3)[CH2:13][CH2:12][C:11]2=[O:36])[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 23048800HCID 23048800, compound

Product 1

HCID 23048822HCID 23048822, compound

Procedure

N-(3-morpholinopropyl)-5-[4-(4-(p-toluenesulfonyloxy)butyl)phenyl]pyrrolidin-2-one and 1-(3-trifluoromethylphenyl)piperazine are reacted together to give N-(3-morpholinopropyl)-5-[4-(4-(4-(3-trifluoromethylphenyl)piperazin-1-yl)butyl)phenyl]pyrrolidin-2-one.

Sources & evidence

ORD record
ord-5536b6c2cb344054a5b83a061171cb35
Source dataset
uspto-grants-1990_06
Patent number
US04931443

Reaction notes

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