Potassium Carbonate → HCID 14423672, compound

Participants

Reaction Steps

20 g of ethyl 4-oxo-4-[4-(4-chlorobutyl)phenyl]butyrate and 12 g of 1-(3-methylphenyl)piperazine are dissolved in a mixed solvent of 80 ml of dimethylformamide and 80 ml of toluene. To this solution, 14 g of potassium carbonate is added, and this is followed by reflux with heating for 18 hours under stirring the solution. After the completion of the reaction, the reaction liquid is concentrated under reduced pressure and extracted with ethyl acetate. After being washed with water, the extract is dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. The resulting oily substance is purified by silica gel column chromatography, after which it is crystallized with isopropyl ether to give 17.2 g of ethyl 4-oxo-4-[4-(4-(4-(3-methylphenyl)piperazin-1-yl)butyl)phenyl ]butyrate having a melting point of 62° to 63° C.

Provenance & Evidence