Sodium Hydroxide → HCID 14423683, compound

Participants

Reaction Steps

This ester is then dissolved in 200 ml of ethanol. To this solution, a solution of 4.7 g of sodium hydroxide in 20 ml of water is added, and this is followed by reflux with heating for 30 minutes. After the completion of the reaction, the solvent is distilled off, and the residue, after dilution with water, is adjusted to pH 5 with hydrochloric acid. The crystals precipitated are collected by filtration and further recrystallized from methanol-isopropyl ether to give 14 g of 4-oxo-4-[4-(4-(4-(3-methylphenyl)piperazin-1-yl)butyl)phenyl]butyric acid having a melting point of 199° to 201° C.

Provenance & Evidence