Hydroxyamine hydrochloride → HCID 86743986, compound

Participants

Reaction Steps

To 14 g of 4-oxo-4-[4-(4-(4-(3-methylphenyl)piperazin-1-yl)butyl)phenyl]butyric acid, 200 ml of ethanol is added. To this mixture, 3.1 g of hydroxylamine hydrochloride and 4.0 g of sodium hydrogencarbonate are further added, and this is followed by reflux with heating for 6 hours under stirring the mixture. After the completion of the reaction, the solvent is distilled off under reduced pressure. To this residue, water is added, and the crystals precipitated are collected by filtration to give 9.7 g of 4-hydroxyimino-4-[4-(4-(4-(3-methylphenyl)piperazin-1-yl)butyl)phenyl ]butyric acid having a melting point of 175° to 177° C.

Provenance & Evidence