HCID 23048955, compound → HCID 10775116, compound

Participants

Reaction Steps

2-Methylphenyl-(3-methyl-2-thienyl)methanol (36.0 g, 0.165 mole) was dissolved in dichloromethane (400 ml) and manganese dioxide (58 g, 0.667 mole) was added. The reaction mixture was heated at reflux for 18 h, cooled and further manganese dioxide (30 g, 0.34 mole) was introduced; reflux was continued for a further 18 h. The mixture was filtered and evaporated to a residue (32 g) which was distilled in vacuo (0.2 mm Hg). Fractions boiling at 100°-120° C. (4.8 g) and 120°-132° C. (21.0 g) were collected, giving the title compound as an oil (25.8 g, 72%).

Provenance & Evidence